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InSilicoVaccine – COVID-19

Enhancing the efficacy of a COVID-19 Vaccine

Background

Covid19- a global pandemic caused by the SARS-CoV-2 virus. In response to the pandemic, researchers are exploring innovative approaches, such as in silico methods, to enhance the efficacy of COVID-19 vaccines and address the challenges associated with traditional vaccine development.

Question of Interest

To determine the potential inclusion of novel vaccine components, including those from BCG and DTP vaccines?

Methods

BIOINFORMATICS: Selection Of Components

Test T and B cell reactivity– Test epitope activity to establish antigenicity.

 

AGENT-BASED MODEL: Dynamic simulations

Agent-based Immune System Simulation- Simulate effect on disease progression in virtual patients.  

Results

In silico trials of vaccine efficacy and immune responses- Simulate SARS-CoV-2 infection in a population of virtual patients.  

Impact

  • In silico methods could help overcome some of the logistical and ethical challenges associated with traditional vaccine development, such as the need for large-scale animal testing or the availability of human volunteers.
  • In silico methods can also be used to optimize vaccine design by predicting the most effective antigen sequences or adjuvants to elicit a robust immune response. This could help improve the efficacy of vaccines and reduce the risk of viral mutations.

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